Non‐alcoholic fatty liver disease in women with polycystic ovary syndrome: systematic review and meta‐analysis
- L. Rocha1 · L. C. Faria2 · T. C. M. Guimarães2 · G. V. Moreira1 · A. L. Cândido2 · C. A. Couto2 · F. M. Reis
J Endocrinol Invest 2017
Overview of PCOS:
- It is endocrine syndrome characterized by triad of amenorrhea, obesity, and hirsutism. The main stay of treatment is combination OCPs.
Article Summary:
- The purpose of the study is to assess the association of PCOS with non-alcoholic fatty liver disease. Like PCOS, NAFLD is associated with obesity, DM, insulin resistance, and metabolic syndrome. PCOS women have increased risk of NAFLD, but it is debatable which features of PCOS affect the NAFLD risk.
- Method: 17 studies published between 2007 and 2017 that included 2,734 PCOS patients and 2561 controls of similar age and BMI.
- Results: PCOS patients have increased prevalence of NAFLD (odds ratio 2.54, 95% confidence interval 2.19-2.95). PCOS women with hyperandrogenism have a higher prevalence of NAFLD compared to women with PCOS without hyperandrogenism. The presence of NAFLD is also associated with high serum total testosterone, in addition to obesity and insulin resistance.
- It is important to know about PCOS because it is common in reproductive women. It can lead to health complication if PCOS is untreated. Besides fertility problems, complications include risk for developing insulin resistance, diabetes, abnormal cholesterol/triglyceride level, heart disease, stroke, obesity, and endometrial cancer.
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