Rotation 2 Trichomoniasis Article

Single-dose compared to multi-dose metronidazole for the treatment of trichomoniasis in women: A meta-analysis

Summary:

• The purpose of this meta-anaylsis was to compare treatment failure between single vs multi-dose metronidazole for treatment of T.vaginalis.
• Both the CDC and WHO currently recommends that individuals be treated a single 2 g dose orally. If treatment failures occurs, CDC recommends 500 mg BID for 7 days and WHO recommends 400-500 mg BID for 7 days
• Methods: a systematic literature search was performed using search terms such as metronidazole AND trichomonas AND women. There were a total of 6 studies included in this meta-analysis
• Women who received a 2g single dose were 1.87 times more likely to have treatment failure than women who received multi-dose (95% C.I 1.23 to 2.82, p<0.003)
• Side effects are reported more in the 2 g dose compared to the multi-dose.
• In conclusion, multi-dose treatment is significantly favor over the single-dose regimen.
• CDC recently changed treatment recommendations for HIV + women to multi rather than single-dose. These data suggest that those recommendations should be considered for all women.

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